Gene information
Official symbol CLU
Official full name clusterin
Gene type protein-coding gene
Chromosome8p21.1
Alias symbolSGP-2; SP-40; TRPM-2; KUB1; CLU1; CLU2
Previous symbolCLI; APOJ
Gene familyComplement system regulators and receptors; MicroRNA protein coding host genes
Resources
Entrez Gene 1191
HGNC HGNC:2095
Ensembl ENSG00000120885
Vega OTTHUMG00000102114
UCSC uc003xfz.3
GO terms: 107 records
GO Description Category LogP Number of genes Detail
GO:0001774 microglial cell activation GO Biological Processes -13.1367436 11 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002253 activation of immune response GO Biological Processes -3.86084748 14 More
GO:0002269 leukocyte activation involved in inflammatory response GO Biological Processes -12.6026553 11 More
GO:0002274 myeloid leukocyte activation GO Biological Processes -20.6988408 25 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002449 lymphocyte mediated immunity GO Biological Processes -8.72662877 18 More
GO:0002455 humoral immune response mediated by circulating immunoglobulin GO Biological Processes -5.71650362 10 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006956 complement activation GO Biological Processes -7.12107226 12 More
GO:0006958 complement activation, classical pathway GO Biological Processes -5.86439052 10 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0007005 mitochondrion organization GO Biological Processes -2.05283627 29 More
GO:0007009 plasma membrane organization GO Biological Processes -3.91866373 17 More
GO:0007272 ensheathment of neurons GO Biological Processes -4.19306733 15 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0008366 axon ensheathment GO Biological Processes -4.19306733 15 More
GO:0008637 apoptotic mitochondrial changes GO Biological Processes -5.28671514 12 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0010001 glial cell differentiation GO Biological Processes -13.0211768 33 More
GO:0010639 negative regulation of organelle organization GO Biological Processes -2.25995266 25 More
GO:0010821 regulation of mitochondrion organization GO Biological Processes -7.09757912 23 More
GO:0010823 negative regulation of mitochondrion organization GO Biological Processes -4.35719226 10 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0014003 oligodendrocyte development GO Biological Processes -2.77180092 7 More
GO:0016064 immunoglobulin mediated immune response GO Biological Processes -6.28897630 13 More
GO:0019724 B cell mediated immunity GO Biological Processes -7.00231964 14 More
GO:0021782 glial cell development GO Biological Processes -9.97103962 23 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030163 protein catabolic process GO Biological Processes -2.20136577 18 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030425 dendrite GO Cellular Components -4.55233052 48 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031625 ubiquitin protein ligase binding GO Molecular Functions -1.82192201 21 More
GO:0031647 regulation of protein stability GO Biological Processes -2.93350742 12 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032760 positive regulation of tumor necrosis factor production GO Biological Processes -21.1788990 23 More
GO:0033218 amide binding GO Molecular Functions -9.50305686 47 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034364 high-density lipoprotein particle GO Cellular Components -15.5094832 12 More
GO:0034366 spherical high-density lipoprotein particle GO Cellular Components -7.69370672 5 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0042063 gliogenesis GO Biological Processes -20.3412228 47 More
GO:0042116 macrophage activation GO Biological Processes -15.3664951 15 More
GO:0042176 regulation of protein catabolic process GO Biological Processes -8.45353494 23 More
GO:0042552 myelination GO Biological Processes -4.28583448 15 More
GO:0042583 chromaffin granule GO Cellular Components -3.23941104 3 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043217 myelin maintenance GO Biological Processes -5.31723275 7 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0044389 ubiquitin-like protein ligase binding GO Molecular Functions -1.61071129 9 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045428 regulation of nitric oxide biosynthetic process GO Biological Processes -19.2075726 26 More
GO:0045429 positive regulation of nitric oxide biosynthetic process GO Biological Processes -13.6962150 18 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0045862 positive regulation of proteolysis GO Biological Processes -17.3242033 33 More
GO:0048156 tau protein binding GO Molecular Functions -1.72986901 3 More
GO:0048260 positive regulation of receptor-mediated endocytosis GO Biological Processes -10.1090317 11 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0048709 oligodendrocyte differentiation GO Biological Processes -4.76121883 12 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050821 protein stabilization GO Biological Processes -2.69690139 9 More
GO:0051087 chaperone binding GO Molecular Functions -6.81600949 11 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051092 positive regulation of NF-kappaB transcription factor activity GO Biological Processes -14.8614421 21 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0061900 glial cell activation GO Biological Processes -13.6981492 12 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070661 leukocyte proliferation GO Biological Processes -8.25401122 12 More
GO:0072562 blood microparticle GO Cellular Components -39.0217600 39 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0080164 regulation of nitric oxide metabolic process GO Biological Processes -19.7892071 27 More
GO:0090199 regulation of release of cytochrome c from mitochondria GO Biological Processes -6.79373102 8 More
GO:0090201 negative regulation of release of cytochrome c from mitochondria GO Biological Processes -3.92689699 4 More
GO:0097190 apoptotic signaling pathway GO Biological Processes -11.7839485 23 More
GO:0097447 dendritic tree GO Cellular Components -4.82959150 49 More
GO:0150076 neuroinflammatory response GO Biological Processes -13.2187099 12 More
GO:1901214 regulation of neuron death GO Biological Processes -23.5458880 37 More
GO:1901216 positive regulation of neuron death GO Biological Processes -5.62852599 9 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1902903 regulation of supramolecular fiber organization GO Biological Processes -5.63791156 37 More
GO:1902904 negative regulation of supramolecular fiber organization GO Biological Processes -2.83678359 16 More
GO:1902905 positive regulation of supramolecular fiber organization GO Biological Processes -5.32876142 22 More
GO:1902947 regulation of tau-protein kinase activity GO Biological Processes -4.91299256 6 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -20.7768498 23 More
GO:1904407 positive regulation of nitric oxide metabolic process GO Biological Processes -14.4967625 19 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001242 regulation of intrinsic apoptotic signaling pathway GO Biological Processes -16.0885267 23 More
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway GO Biological Processes -12.4318822 16 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
Drug-Gene interaction
view
Related drugs: 3 records
Drug name Interaction type Source PMID View
custirsen antisense oligonucleotide TALC view
custirsen sodium inhibitor TdgClinicalTrialCancerCommons view
lubiprostone TdgClinicalTrial view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
clusterin proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Cubedo J et al. J Proteome Res. 2011
clusterin proteomics left ventricular remodeling[prognosis (bad)] acute anterior myocardial infarction Turkieh A et al. Circ Heart Fail. 2018
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